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罗岚蓉,李坚
《中国工程科学》 2015年 第17卷 第6期 页码 65-69
用于细胞活动可调式光遗传学操控的无线程控LED阵列的研究开发
齐元楷,陈俊晔,刘雪纯,周晓旭,樊剑南,申屠平,Olof Idevall-Hagren,许迎科
《工程(英文)》 2018年 第4卷 第6期 页码 745-747 doi: 10.1016/j.eng.2018.08.005
一种使用光学可控生物致动器的微蠕动泵 Article
Eitaro Yamatsuta, Sze Ping Beh, Kaoru Uesugi, Hidenobu Tsujimura, Keisuke Morishima
《工程(英文)》 2019年 第5卷 第3期 页码 580-585 doi: 10.1016/j.eng.2018.11.033
新孢子虫病——分子流行病学及发病机制综述 Review
Asis Khan, Jahangheer S. Shaik, Patricia Sikorski, Jitender P. Dubey, Michael E. Grigg
《工程(英文)》 2020年 第6卷 第1期 页码 10-19 doi: 10.1016/j.eng.2019.02.010
人类蛋白质N-糖基化的十二年全基因组关联研究 Review
Anna Timoshchuk, Sodbo Sharapov, Yurii S. Aulchenko
《工程(英文)》 2023年 第26卷 第7期 页码 17-31 doi: 10.1016/j.eng.2023.03.013
Most human-secreted and membrane-bound proteins have covalently attached oligosaccharide chains, or glycans. Glycosylation influences the physical and chemical properties of proteins, as well as their biological functions. Unsurprisingly, alterations in protein glycosylation have been implicated in a growing number of human diseases, and glycans are increasingly being considered as potential therapeutic targets, an essential part of therapeutics, and biomarkers. Although glycosylation pathways are biochemically well-studied, little is known about the networks of genes that guide the cell- and tissue-specific regulation of these biochemical reactions in humans in vivo. The lack of a detailed understanding of the mechanisms regulating glycome variation and linking the glycome to human health and disease is slowing progress in clinical applications of human glycobiology. Two of the tools that can provide much sought-after knowledge of human in vivo glycobiology are human genetics and genomics, which offer a powerful data-driven agnostic approach for dissecting the biology of complex traits. This review summarizes the current state of human populational glycogenomics. In Section 1, we provide a brief overview of the N-glycan's structural organization, and in Section 2, we give a description of the major blood plasma glycoproteins. Next, in Section 3, we summarize, systemize, and generalize the results from current N-glycosylation genome-wide association studies (GWASs) that provide novel knowledge of the genetic regulation of the populational variation of glycosylation. Until now, such studies have been limited to an analysis of the human blood plasma N-glycome and the N-glycosylation of immunoglobulin G and transferrin. While these three glycomes make up a rather limited set compared with the enormous multitude of glycomes of different tissues and glycoproteins, the study of these three does allow for powerful analysis and generalization. Finally, in Section 4, we turn to genes in the established loci, paying particular attention to genes with strong support in Section 5. At the end of the review, in Sections 6 and 7, we describe special cases of interest in light of new discoveries, focusing on possible mechanisms of action and biological targets of genetic variation that have been implicated in human protein N-glycosylation.
王宏建,李靖,刘和光,姜景山
《中国工程科学》 2004年 第6卷 第11期 页码 38-42
文章通过电磁场时域有限差分(FDTD)算法与遗传算法(GA)相结合进行平面螺旋电感设计。通过优化单元网格大小,可优化设计整个平面螺旋电感(包含空气桥)的结构尺寸。
陈涛,苏国锋,疏学明,袁宏永,范维澄
《中国工程科学》 2004年 第6卷 第7期 页码 60-64
桂建芳,包振民,张晓娟
《中国工程科学》 2016年 第18卷 第3期 页码 8-14 doi: 10.15302/J-SSCAE-2016.03.002
20多年来,随着水生生物学和生物技术的发展,我国在水产遗传育种与种业方面取得了诸多进展,但也面临着机遇和挑战。本文围绕种质资源保存与利用、遗传机制解析与功能基因挖掘、优良性状新品种选育、水产种业建设等,开展国内外遗传育种现状对比分析研究,分析了当前存在的一些问题,提出未来特别是“十三五”期间水产遗传育种科技发展目标和重点任务。
王宏建,高本庆,刘瑞祥
《中国工程科学》 2002年 第4卷 第5期 页码 84-87
采用遗传算法来优化单脉冲阵列天线的和、差方向图和方向性系数。
王英
《中国工程科学》 2008年 第10卷 第7期 页码 57-59
分析了遗传算法及退火算法的优缺点,提出用退火算法改进遗传算法局部的最优值搜索效率低问题。退火算法与遗传算法融合后,使算法在寻优结果上更加迅速精确。通过水泥的配比工程实例,与单纯的遗传算法的结果进行对比,说明该方法是有效的。
标题 作者 时间 类型 操作
一种使用光学可控生物致动器的微蠕动泵
Eitaro Yamatsuta, Sze Ping Beh, Kaoru Uesugi, Hidenobu Tsujimura, Keisuke Morishima
期刊论文
新孢子虫病——分子流行病学及发病机制综述
Asis Khan, Jahangheer S. Shaik, Patricia Sikorski, Jitender P. Dubey, Michael E. Grigg
期刊论文
中国遗传学会基因组编辑分会第二次会员代表大会暨全国学术年会
2019年11月22日
会议信息